Serum C-Peptide Levels in Diabetes Mellitus Type II
DOI:
https://doi.org/10.58987/74p17n68Keywords:
Serum C-Peptide, Insulin, Glycosylated Hemoglobin, Proinsulin, Type-II Diabetes MellitusAbstract
The role of serum C-peptide in estimating the exact amount of insulin secreted endogenously is getting substantial amount of recognition, just because C-peptide has no biologic activity on homologous or heterologous tissue and no ability to modify the action of insulin and/or proinsulin. The present study is to evaluate the serum C-peptide levels in type-2 diabetic patients and to compare their levels with those of matched healthy controls. Approximately, 56 cases of type- II diabetes mellitus (35 males, 21 females) were subjected to analysis of serum C-peptide, blood sugar (fasting, post meal), glycosylated hemoglobin, and lipid profile. The results were compared with age and sex matched healthy controls. It was seen that serum C-peptide level is significantly (p<0.001) decreased in long-standing type-2 diabetic patients as compared to sex and age matched apparently healthy controls. There is decrease in concentration of fasting serum C-peptide level both in male and female type-2 diabetic patients as compared to matched controls. As compared to matched control, the decrease is highly significant (p<0.001 and p<0.05). There was no significant difference in the concentration of serum C-peptide between males and females. The data suggests that insulin resistance is an avoidable consequence of abdominal fat accumulation with advancing age. This work strongly confirms the earlier views of C-peptide being a valuable parameter in assessing progress of disease.
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